JacqueLENS PhD - Prevalence of neuromyelitis optica spectrum disorder

Journal article

F. Briggs, Jacqueline Shaia
Multiple Sclerosis, 2024

Cite

APA Click to copy
Briggs, F., & Shaia, J. (2024). Prevalence of neuromyelitis optica spectrum disorder in the United States. Multiple Sclerosis.

Chicago/Turabian Click to copy
Briggs, F., and Jacqueline Shaia. “Prevalence of Neuromyelitis Optica Spectrum Disorder in the United States.” Multiple Sclerosis (2024).

MLA Click to copy
Briggs, F., and Jacqueline Shaia. “Prevalence of Neuromyelitis Optica Spectrum Disorder in the United States.” Multiple Sclerosis, 2024.

BibTeX Click to copy

@article{f2024a,
  title = {Prevalence of neuromyelitis optica spectrum disorder in the United States.},
  year = {2024},
  journal = {Multiple Sclerosis},
  author = {Briggs, F. and Shaia, Jacqueline}
}

Abstract

BACKGROUND Neuromyelitis optic spectrum disorder (NMOSD) is a rare demyelinating, autoimmune disease and the burden in United States is not well characterized.

OBJECTIVE The objective of this study was to determine the 2022 US prevalence of NMOSD.

METHODS We constructed a cross-sectional study using aggregated electronic health record data for 25.7 million patients who had a 2022 clinical encounter. The data originated from the TriNetX US Collaborative Network of 55 healthcare organizations that span all 50 states. NMOSD prevalence was determined by querying for age-interval, sex, and race combinations, with direct standardization to the 2022 US Census data.

RESULTS There were 1772 NMOSD patients among 25,743,039 patients for a prevalence of 6.88/100,000. Prevalence was the highest in Blacks (12.99/100,000) who represented 27.7% of NMOSD patients, then Asians (9.41/100,000and Whites (5.58/100,000). Among females, the prevalence of NMOSD was 9.48/100,000, and Black and Asian females had a 2.65- and 1.94-times higher prevalence than White females. In males, the prevalence of NMOSD was 3.52/100,000 and it did not differ by race. We observed a 3/5:1 female-to-male ratio in NMOSD. The age- and sex-adjusted 2022 estimate of persons with NMOSD in the United States was 15,413 females and 6233 males.

CONCLUSION We estimate that there were near 22,000 Americans living with NMOSD in 2022.